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ADC Linkers

Azide-PEG8-Val-Cit-PABC-SN-38

Catalog: TASK-21-2000074   CAS NO.: N/A
  • 5mg
  • 10mg
  • 25mg

$68.25$68.25

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Description

Azide-PEG8-Val-Cit-PABC-SN-38 is a cleavable ADC linker with the SN-38 payload. Azide can be used as a reactive handle for bioconjugation reactions. It allows for the attachment of other molecules, such as polyethylene glycol (PEG) or linkers, to the ADC. Val-Cit is a linker molecule that connects the antibody to the cytotoxic drug payload. It plays a crucial role in stabilizing the ADC and controlling the release of the cytotoxic drug once the ADC is internalized by the cancer cell. PABC (p-aminobenzyl carbamate) is another type of linker molecule used in ADCs. It connects the Val-Cit linker to the cytotoxic drug payload and helps in stabilizing the ADC. PABC linkers are designed to facilitate the release of the cytotoxic drug within the cancer cell. SN-38 is the cytotoxic drug payload, which is a derivative of irinotecan. It inhibits topoisomerase I, leading to DNA damage and cell death in cancer cells.

Specifications

CAS No.N/A
FormulaC63H87N11O21
Molecular Weight1334.5
Purity95%
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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