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Liposomes

Mirdametinib (PD0325901) Liposomes, Formulation U6-2, Lyophilized Powder | CAS 391210-10-9

Catalog: TASK-25-6000033   CAS NO.: 391210-10-9
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  • 100mg

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Description

Mirdametinib (PD0325901) Liposomes, Formulation U6-2, Lyophilized Powder are widely used in the treatment of cancers that are driven by MEK1/2 activation or mutations in the RAS/RAF/MEK/ERK signaling pathway. This includes both solid tumors and hematologic cancers where aberrant MEK activity plays a critical role in tumor progression. The most well-studied application of Mirdametinib is in the treatment of BRAF-mutant melanoma, where the MAPK pathway is constitutively activated. Although BRAF inhibitors are effective initially, resistance often develops due to feedback activation of MEK. Liposomal Mirdametinib (U6-2) can be used either alone or in combination with BRAF inhibitors to overcome resistance and provide more durable responses. Besides, NSCLC with KRAS mutations or BRAF mutations often exhibit hyperactivation of the MEK/ERK pathway. Liposomal Mirdametinib has the potential to target these tumors effectively, reducing tumor growth and metastasis.

Specifications

CAS No.391210-10-9
Lipid CompositionN/A
FormLyophilized Powder
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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