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AR-42 | CAS 935881-37-1

Catalog: TASK-37-1000593   CAS NO.: 935881-37-1
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Description

AR-42 ((αS)-N-[4-[(Hydroxyamino)carbonyl]phenyl]-α-(1-methylethyl)benzeneacetamide / (S)-(+)-N-Hydroxy-4-(3-methyl-2-phenyl-butyrylamino)-benzamide) has a central structure that is typically a hydroxamic acid derivative. Hydroxamic acids are known for their ability to chelate metal ions, which is crucial for their activity as HDAC inhibitors. The presence of hydroxamic acid group (-C(O)NOH) is key for binding to the active site of HDAC enzymes. This group coordinates with zinc ions in the enzyme’s active site, inhibiting its activity. AR-42 induces apoptosis (programmed cell death) in cancer cells by disrupting the normal balance of acetylation and deacetylation, leading to activation of pro-apoptotic genes and suppression of anti-apoptotic genes. The compound causes cell cycle arrest at different phases, depending on the type of cancer cell. This effect is due to the alteration of gene expression related to cell cycle regulation. This product is available in kilograms. Please kindly contact us if you are in request.

Specifications

CAS No.935881-37-1
FormulaC18H20N2O3
Molecular Weight312.36
Purity>98%
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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