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PEG Linkers with Small Molecular

Azido-PEG3-Val-Cit-PAB-PNP | CAS 2055047-18-0

Catalog: TASK-18-1003038   CAS NO.: 2055047-18-0
  • 100mg
  • 250mg

$68.25$68.25

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Description

Azido-PEG3-Val-Cit-PAB-PNP s a compound utilized in the development of antibody-drug conjugates (ADCs), a class of targeted therapeutics for cancer treatment and potentially other diseases. The azido group facilitates the attachment of the ADC to a targeting antibody or other biomolecules bearing complementary reactive groups, such as alkynes. The PAB moiety acts as a cleavable linker that connects the cytotoxic drug payload to the rest of the linker structure. It is engineered to be stable in circulation but undergoes enzymatic cleavage within target cells, facilitating the release of the cytotoxic drug and exerting its therapeutic effect. PNP is a leaving group that participates in the conjugation reaction. It reacts with nucleophiles, such as primary amines on the targeting antibody or drug payload, forming stable amide bonds. This reaction is typically performed under mild conditions, preserving the integrity and activity of the biomolecules involved.

Specifications

CAS No.2055047-18-0
FormulaC34H47N9O12
Molecular Weight773.8
Purity98%
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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