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Biotinylation Reagents

DBCO-NH-PEG12-Biotin | CAS 2621391-31-7

Catalog: TASK-36-1000769   CAS NO.: 2621391-31-7
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$68.25$68.25

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Description

DBCO-NH-PEG12-Biotin combines the reactive properties of DBCO, versatility of NH for bioconjugation, solubility and stability of PEG12, and targeting specificity of biotin. DBCO is a cyclooctyne derivative known for its reactivity in bioorthogonal chemistry, particularly in strain-promoted azide-alkyne cycloaddition (SPAAC). It forms stable triazole linkages with azide-containing molecules or surfaces under mild, physiological conditions without the need for toxic copper catalysts. The NH group typically refers to an amine functional group (-NH2) which can participate in bioconjugation reactions. It allows for versatile conjugation strategies, such as amidation reactions with carboxyl groups or NHS esters, enabling attachment to various biomolecules or surfaces. PEG is a hydrophilic polymer known for its biocompatibility, non-immunogenicity, and ability to enhance solubility and stability of conjugated molecules. Biotin (vitamin B7) is a small molecule that exhibits high affinity and specificity for streptavidin and avidin proteins. It serves as a targeting moiety in bioconjugation applications, allowing specific binding to streptavidin-conjugated molecules, surfaces, or nanoparticles.

Specifications

CAS No.2621391-31-7
FormulaC55H83N5O16S
Molecular Weight1102.3
Purity>98%
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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