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ADC Linkers


Catalog: TASK-21-1000053   CAS NO.: N/A
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DBCO-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). DBCO is a chemical group used in bioconjugation, particularly in click chemistry. It’s reactive with compounds containing azide groups. The Val-Cit is specifically cleaved by cathepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell. PAB-OH is frequently used as a linker to attach other molecules, such as drugs or imaging agents, to a targeting ligand.


Molecular Weight1090.3
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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