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endo-BCN-PEG4-Val-Cit-PAB-MMAE

Catalog: TASK-20-2000036   CAS NO.: 2762519-08-2
  • 5mg
  • 10mg

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Description

endo-BCN-PEG4-Val-Cit-PAB-MMAE is a peptide ADC linker with a BCN group. Endo-BCN is a strained cyclic alkyne compound utilized in bioorthogonal chemistry. It facilitates selective and efficient conjugation to azide-functionalized molecules or surfaces via strain-promoted azide-alkyne cycloaddition (SPAAC) reactions. PAB is a moiety often used in drug conjugates for targeted delivery. It serves as a cleavable linker, allowing for controlled release of the attached payload (in this case, MMAE) inside target cells. MMAE is a potent cytotoxic agent derived from the natural product dolastatin 10. It inhibits cell division by disrupting microtubule dynamics, making it effective against rapidly dividing cancer cells.

Specifications

CAS No.2762519-08-2
FormulaC80H127N11O19
Molecular Weight1547.0
Purity98%
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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