Description
Fmoc-L-Gln(Trt)-NHN=Pyv Resin (Fmoc-N-gamma-trityl-L-glutaminyl-hydrazono-pyruvyl-aminomethylpolystyrene resin) represents an ideal choice for creating peptide-drug conjugates, peptide-polymer conjugates, fluorescent peptide conjugates, peptide-protein conjugates, and peptide libraries. Its versatility in targeted therapeutics, diagnostics, and post-translational modifications makes it invaluable for drug delivery systems, immunology research, and glycobiology studies. The trityl (Trt) protection on the gamma-amino group of glutamine (Gln) is designed to shield the side chain amine from unwanted reactions during peptide synthesis. The trityl group is bulky and sterically hindered, making it highly effective in preventing reactions that might otherwise occur at the side chain during the coupling process. The hydrazone bond is stable under physiological conditions, but it can be selectively cleaved under acidic or basic conditions, allowing for the controlled release of the conjugated molecule or for further modifications to be introduced. This feature is particularly useful in developing peptide-drug conjugates, peptide-targeting agents, and peptide-based diagnostics. Polystyrene resin is an essential material for a wide range of uses in research, diagnostics, medical devices, and multiple industial applications from packaging to construction. Taskcm can provide polystyrene resins in kilograms. Please contact us if you are in need of this product.
