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APIs & Intermediates

(+)-trans-anti-BPDE-N2-dG | CAS 65437-20-9

Catalog: TASK-37-1000118   CAS NO.: 65437-20-9
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Description

(+)-trans-anti-BPDE-N2-dG ((+)-trans-anti-Benzo[a]pyrene-dG / 10S(+)-trans-anti-[Py]-N2-dG / [7R-(7α,8β,9β,10α)]-2'-deoxy-N-(7,8,9,10-tetrahydro-7,8,9-trihydroxybenzo[a]pyren-10-yl)guanosine / Benzo[a]pyrene, guanosine deriv. / (+)-r-7,t-8-Dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene-dG / (+)-trans-anti-7,8,9-Trihydroxy-10-(2'-deoxyguanosin-2-yl)benzo[a]pyrene) is a crucial adduct formed between benzo[a]pyrene diol epoxide and deoxyguanosine, playing a significant role in cancer research. It provides valuable insights into the mutagenic processes induced by environmental carcinogens and helps in developing strategies for cancer prevention and treatment. BPDE is a highly reactive metabolite of benzo[a]pyrene, a polycyclic aromatic hydrocarbon found in tobacco smoke and other environmental pollutants. BPDE forms adducts with cellular macromolecules, including DNA, leading to mutagenic and carcinogenic effects. Deoxyguanosine is one of the four nucleosides in DNA, and the N2 position of its guanine base is a common site for adduct formation with BPDE. This product is available in kilograms. Please kindly contact us if you are in request.

Specifications

CAS No.65437-20-9
FormulaC30H27N5O7
Molecular Weight569.56
Purity>98%
Ship Within1 week
Storage Temp.N/A
Shipping4-25℃ for up to 3 weeks
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