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ADC Linkers


Catalog: TASK-21-1000041   CAS NO.: 1964490-09-2
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Mal-Amide-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). Maleimide groups are known for reacting specifically with thiol (-SH) groups, such as those present in cysteine residues of proteins. Amide bonds are commonly used for linking different molecules together, and they are found in various bioconjugation strategies. The Val-Cit is specifically cleaved by cathepsin B. PAB is often used as a linker in drug conjugates to attach other molecules, such as cytotoxic drugs or imaging agents, to a targeting ligand. PNP is a good leaving group when reacting with amine containing molecule.


CAS No.1964490-09-2
Molecular Weight1119.2
Ship Within1 week
Storage Temp.-20℃
Shipping4-25℃ for up to 3 weeks
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